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Origin: Periphery
Markers: CD4+, CD25 high, FoxP3 high, CD45RA-, CD45RO+, CD127 low HLA-DR -, CD95+, CTLA4+, Ki67+, ICOS+/-
Key features: Regulatory T Cells (Tregs) suppress T cell responses
CD4+ CD25++ FOXP3 low nTreg / tTreg are transformed extrathymically at peripheral sites to CD4+ CD25+ FOXP3 high Treg (peripherally induced) by TGF-beta from APCs
However, CD4+ CD25+ FOXP3 high Treg (peripherally induced) are generated from Naive CD4+ T Cells rather than in the…