meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond
Citrobacter rodentium & Group 3 ILCs
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Contents
HOIL1 restricts early intestinal replication and systemic spread of Citrobacter rodentium. It functions partly in myeloid cells to limit morbidity and systemic spread and promotes Group 3 ILCs (ILC3) expansion and Interleukin-22 (IL-22) expression during Citrobacter rodentium infection.
G-Protein Coupled Receptor 43 (GPR43) is required for normal expansion of Group 1 ILCs (ILC1) and Group 3 ILCs in both the [intestine](brain://2ze-J2p2VEi_0VSpadeLHw/Intes…
References (Sources)
- CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut
- Dietary fiber metabolites regulate innate lymphoid cell responses
- HOIL1 Regulates Group 3 Innate Lymphoid Cells in the Colon and Protects against Systemic Dissemination, Colonic Ulceration, and Lethality from Citrobacter rodentium Infection
- Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.