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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

CD4+ CD25+ Treg

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Markers: CD4+, CD25+, CD62L+, CTLA-4+, FoxP3+

MHC-II-presented polysaccharide A (PSA) and possibly other T cell-dependent polysaccharides are recognized explicitly by CD4+ T cells with regulatory T cell activity
Johnson et al. 2015a Journal of Biological Chemistry 290: 5007-5014

Differentiation of T Regulatory Cells by Immature Dendritic Cells
Roncarolo et al., 2001
Ex vivo isolation and characterization of Cd4+Cd25+ T cells with regulatory properties from human blood
Dieckmann et al. 2001 J Exp Med 193: 1303-1310
Expression of Helios in peripherally induced Foxp3+ regulatory T cells
Gottschalk et al. 2012 J Immunol 188(3): 976-980
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
Thornton et al. 2010 J Immunol 184(7): 3433-3441
Helios expression is a marker of T cell activation and proliferation
Akimova et al. 2011 PLoS One 6(8): e24226
Naturally arising CD4+ regulatory T cells for immunologic selftolerance and negative control of immune responses
Sakaguchi et al. 2004 Annu Rev Immunol 22: 531-62
Review
Polysaccharide A from the Capsule of Bacteroides fragilis Induces Clonal CD4+ T Cell Expansion
Johnson et al. 2015a Journal of Biological Chemistry 290: 5007-5014

12/16/2025