Gut microbiota & RAR-related Orphan Receptor Gamma/T (ROR-gamma/t) Isoform 2 (NR1F3)t + Foxp3 + Colonic Treg cells

The gut microbiota and selected strains of Commensal Bacteria / Commensalism affect the functionality of RAR-related Orphan Receptor Gamma/T (ROR-gamma/t) Isoform 2 (NR1F3)t+ Foxp3+ Colonic Treg cells
Byun et al. 2024 J Immunol 213(6): 886–897

Treg cell frequencies are particularly high in the lamina propria , especially in the colon, and they positively corelate with the microbial mass in the GI tract
Atarashi et al. 2011
Stephen-Victor et al. 2020 Immunity 53(2): 277-289

Gut bacteria control colonic RORγ +T reg cells through their bile acid metabolic pathways
Song et al. 2019b Nature 577(7790): 410-415

Gut tissue-resident Regulatory T Cells (Tregs) can be induced in response to dietary and Gut microbiota
Kim et al. 2016 Science 351: 858-863
Russler-Germain et al. 2017 Mucosal Immunol. 10: 1375-1386

The symbiosis of gut bacteria is made possible because of a tolerized response from the Mucosal immune system
Gurav et al. 2015 Biochem J. 469(2): 267-278

Bacteroides fragilis has been shown to produce polysaccharide A (PsA), which also stimulates regulatory T cell production.
Zeng & Chi 2015 Trends Immunol. 36: 3-12

Specific members of the commensal microbial community have been found to potentiate the generation of anti-inflammatory Regulatory T Cells (Tregs) or pro-inflammatory Th17 cells
Ivanov et al. 2009
Round & Mazmanian 2010
Atarashi et al. 2011
Lathrop et al. 2011
Atarashi et al. 2013 Nature 500: 232

Specific Commensal Bacteria / Commensalism species induce the accumulation of specific immune cell populations, for example, Foxp3＋ Tregs
Atarashi et al. 2011
Atarashi et al. 2013 Nature 500: 232

Gut commensal microbes shape the Mucosal immune system by regulating the differentiation and expansion of several types of T cell
Furusawa et al. 2013

Treg cells expressing transcription factor Foxp3 play a key role in limiting inflammatory responses in the intestine
Josefowicz et al. 2012

Gut microbiota induces an efficient peripheral extrathymically generation of antigen-specific populations of Treg cells instead of T effector cells
Lathrop et al. 2011

The induction of generation of RAR-related Orphan Receptor Gamma/T (ROR-gamma/t) Isoform 2 (NR1F3)t + Foxp3 + Colonic Treg cells by gut microbiota provides tolerance to commensal microbiota.
Lathrop et al. 2011

see also:
Biological effects / Functions & Candidatus Savagella (Segmented filamentous bacteria/SFB)
Chemosensory receptors / Chemoreceptor
Regulatory T Cells (Tregs) & Short-Chain Fatty Acids (SCFAs)
T cell differentiation