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Tumor Necrosis Factor alfa (TNF-alfa) acts via Tumor necrosis factor receptor 1 (TNFR1)
The pro-inflammatory cytokine Tumor Necrosis Factor alfa (TNF-alfa) plays a crucial role in orchestrating the inflammatory response by promoting further production of cytokines and chemokines via TNFR1-induced NFKB activation.
Tumor Necrosis Factor alfa (TNF-alfa) is produced in: Monocytes, macrophages, CD4+ T cells, B cells, neutrophils, NK cells, mast cells, fibroblasts, astrocytes, microglia, Endothelial Cells / Endothelium, smooth muscle cells, intrinsic renal cells, keratinocytes
Tumor Necrosis Factor alfa (TNF-alfa) is a central mediator of inflammation and key target for intervention in inflammatory diseases such as rheumatoid arthritis, psoriasis and Crohn's disease.