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Interleukin-18 (IL-18) is a neutrophil chemoattractant and belongs to Interleukin-1 (IL-1) / Interleukin-1 family.
Interleukin-18 (IL-18), a member of the Interleukin-1 (IL-1) / Interleukin-1 family, is processed into a biologically active mature form by caspase 1
Interleukin-18 (IL-18) circulates in the range of tens of nanograms/mL
Interleukin-18 (IL-18) binds to its specific Interleukin-18 Receptor 1 (IL-18R1), also known as IL-1R7
Interleukin-18 (IL-18) uses the same signaling pathway (via inflammasome signalling pathway) as Interleukin-1 (IL-1) / Interleukin-1 family to activate NFKB and induce inflammatory mediators such as Cell adhesion molecule, chemokines, and Fas ligands.
Interleukin-18 (IL-18) also binds with high affinity to the circulating Interleukin-18-binding protein (IL18BP) so that only unbound free IL-18 is active
Interleukin-18 (IL-18) is involved in the activation of CD4+ Th1 Cells, Natural killer cells (NK cells), Th2, gamma/delta T17 cells, and macrophages
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor) is a protein which in humans is encoded by the il-18 gene.The protein encoded by this gene is a proinflammatory cytokine. Many cell types, both hematopoietic cells and non-hematopoietic cells, have the potential to produce IL-18. It was first described in 1989 as a factor that induced interferon-gamma production in mouse spleen cells. Originally, IL-18 production was recognized in Kupffer cells, liver-resident macrophages. However, IL-18 is constitutively expressed in non-hematopoietic cells, such as intestinal epithelial cells, keratinocytes, and Endothelial Cells / Endothelium. IL-18 can modulate both innate and adaptive immunity and its dysregulation can cause autoimmune or inflammatory diseases.
In lymph nodes major source of IL-18 are subcapsular sinus macrophages
IL-18 is a cytokine that promotes gut epithelial integrity
IL-18 as SB-485232 (= rhIL-18 (recombinant human IL-18) being tested as an immunotherapy in cancer
Interleukin-18 (IL-18) = Interferon Type II (IFN Type II) / Interferon Gamma (IFN-g) inducing factor
IL-18 is antiangiogenic
Although Interleukin-18 (IL-18) lacks the pyrogenic activity of IL-1 beta, it is involved in the induction of several secondary pro-inflammatory cytokines, chemokines, cell Cell adhesion molecule, and nitric oxide synthesis
see also:
Interleukin-18 Receptor 1 (IL-18R1)