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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Intestinal Stem Cells (ISCs)

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Contents

The accepted model suggests that Lgr5+ crypt-base columnar (CBC) cells cells are the only intestinal stem cell (ISC) compartment. Studies have shown that Lgr5+ cells are not essential for intestinal regeneration. Two main hypotheses arise from this:

The existence of a quiescent reserve Intestinal Stem Cells (ISCs)

Differentiated cell plasticity

Malagola et al. 2024 Cell 187(12): 3056-3071

Findings, supported by in vivo lineage tracing, reveal:

Lgr5 is not a specific marker for Intestinal Stem Cells (ISCs)

Stemness potential extends beyond the crypt base to the isthmus region.

Undifferentiated cells in the isthmus contribute to [intestinal homeostasis](brain://43U2jXbxY0el…

References (Sources)

Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development
Kim et al. 2022b Immunity 55: 2300-2317
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.
Lindemans et al. 2015 Nature 528: 560–564
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease
Hanash et al. 2012 Immunity 37: 339–350
Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay
Wang et al. 2013 Gastroenterology 145(2): 383-95
Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury
Malagola et al. 2024 Cell 187(12): 3056-3071
Tales from the crypt: new insights into intestinal stem cells
Gehart & Clevers 2019 Nat Rev Gastroenterol Hepatol. 16(1): 19-34
Review
Time-resolved fate mapping identiﬁes the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells
Capdevila et al. 2024 Cell 187(12): 3039-3055

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12/16/2025

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