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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

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Akkermansia muciniphila & Adiposity / Obesity

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Background

The presence of Akkermansia muciniphila inversely correlates with body weight in rodents and humans. The abundance of A. muciniphila decreased in obese and type 2 diabetic mice.
Everard et al. 2013 Proc. Natl. Acad. Sci. USA 110: 9066-9071

Clinical data

The randomized clinical phase II treatment trial NCT04797442 - Akkermansia muciniphila WST01 vs Placebo & Adiposity / Obesity or Type 2 Diabetes (T2D) revealed that the metabolic benefits of A. muciniphila supplementation might rely on its initial levels in the intes…

References (Sources)

Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: Efficacy depends on its baseline levels in the gut
Zhang et al. 2025 Cell Metab 37(3): 592-605
Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms
Cani et al. 2022 Nat Rev Gastroenterol Hepatol 19(10): 625-637
Review
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced adiposity/obesity
Everard et al. 2013 Proc. Natl. Acad. Sci. USA 110: 9066-9071

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4/13/2026

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