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Naive and memory B cells encounter antigens that are transported into the structure by M cells. When an antigen-specific naive or memory B-cell encounters an antigen via its BCR, it is activated. After activation, antigen-specific B cells proliferate within the subepithelial dome.
Bemark et al. 2024 J Immunol 45(3): 211
The GI mucosa is considered the biggest human lymphoid organ.
Gut-associated, lymphoi…