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Interleukin-10 (IL-10) is a crucial anti-inflammatory cytokine that limits immune cell activation and cytokine production. IL-10 Deficiency leads to severe inflammatory bowel disease in humans and mice; the mechanism of inflammation suppression by IL-10 is not fully understood.
Interleukin-10 (IL-10) signaling regulates sphingolipid metabolism in macrophages in response to inflammatory stimuli, both in vitro and in vivo.
The discovery of Interleukin-10 (IL-10) over 30 years ago marked a significant milestone in our understanding of cytokine regulation of immune responses, particularly through the cross-regulation between CD4+ Th1 cells & Cytokines and CD4+ Th2 Cells & Cytokines
Initially, Interleukin-10 (IL-10) was identified as a Th2 cytokine. This classification was based on its strong association with CD4+ Th2 cells clones in mice. However, in humans, both CD4+ Th1 Cells and CD4+ Th2 cells clones were found to secrete IL-10, indicating a more complex role. As research progressed, the anti-inflammatory action of Interleukin-10 (IL-10) gained more attention. This shift in focus highlighted its broader role beyond merely inhibiting CD4+ Th1 Cells. The suppression of antigen-presenting cells (APCs) by IL-10 may indirectly lead to the inhibition of CD4+ Th1 Cells.
Interleukin-10 (IL-10) is a prototype of cytokines that control tissue Inflammation / Inflammatory Diseases and antipathogen immunity
Suppression of the inflammatory cytokines is dependent on IL-10
Interleukin-10 (IL-10) family: IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29
Interleukin-10 (IL-10) is produced in T cells / T lymphocytes, B cells / B Lymphocytes, monocytes, M2 macrophages (CD68+ CD163+), Dendritic Cells (DCs), Mastocytes / Mast cells, Thymopoiesis / Thymocyte, Keratinocytes
see also:
Colitis / Intestinal Inflammation & Interleukin-10 (IL-10)
Inflammatory Bowel Disease (IBD) & Interleukin-10 (IL-10)
Interleukin-10 (IL-10) receptor
Self antigens / Autoantigens / Autoimmunity